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Characterization and Biological Activity of Rutin Extracted from Filipendula ulmaria (L.) Maxim.

Anna Vesnina1,2, Violeta Le1, Svetlana Ivanova3,4

  • 1Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Kemerovo 650000, Russia.

Biotech (Basel (Switzerland))
|March 27, 2026
PubMed
Summary

Filipendula ulmaria is a novel source of high-purity rutin, yielding 2.85% and demonstrating significant health benefits. This flavonoid effectively normalized blood glucose, insulin resistance, and improved liver health in rat studies.

Keywords:
Filipendula ulmaria (L.) Maximbioactivitybiologically active substancesextractionmetabolic syndromerutin

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Area of Science:

  • Pharmacognosy
  • Phytochemistry
  • Natural Product Chemistry

Background:

  • Filipendula ulmaria (L.) Maxim, a Rosaceae family plant, is explored as a novel source for pharmaceutical-grade rutin.
  • Rutin, a widely recognized flavonoid, possesses various biological activities and therapeutic potentials.

Purpose of the Study:

  • To investigate Filipendula ulmaria as a viable and efficient source for extracting high-purity rutin.
  • To evaluate the biological activities of rutin isolated from Filipendula ulmaria in vivo.

Main Methods:

  • Ethanol extraction and fractionation were employed to isolate rutin from dried Filipendula ulmaria plant parts.
  • Rutin purity and phase composition were confirmed using X-ray diffraction (XRD) analysis and Nuclear Magnetic Resonance (NMR) measurements.
  • In vivo studies on rats were conducted to assess the biological effects of the isolated rutin.

Main Results:

  • A yield of 2.85% rutin was achieved from Filipendula ulmaria, which is 1.2 times higher than reported in similar studies.
  • Isolated rutin demonstrated significant in vivo efficacy in normalizing blood glucose, glycosylated hemoglobin, and insulin resistance (HOMA-IR index).
  • The study confirmed rutin's ability to mitigate liver damage induced by high-fat/high-carbohydrate diets, correcting lipid profiles and reducing liver steatosis.

Conclusions:

  • Filipendula ulmaria represents a promising and abundant source for pharmaceutical-grade rutin extraction.
  • The isolated rutin exhibits potent therapeutic effects, particularly in managing metabolic disorders and liver health.
  • This discovery supports the potential application of Filipendula ulmaria-derived rutin in the food technology and pharmaceutical industries.