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Related Concept Videos

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

6.0K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
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Functions of the Nervous System01:18

Functions of the Nervous System

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The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...
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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Role of Septins01:02

Role of Septins

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Neurotransmitters01:31

Neurotransmitters

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Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Related Experiment Video

Updated: Mar 29, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System.

Yuchen Jiao1, Chuangui Wang1, Shengping Zhang1

  • 1Biomedical Research Institute, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.

Cells
|March 27, 2026
PubMed
Summary

Sirtuin 7 (SIRT7), a nucleolar deacetylase, regulates crucial cellular processes and contributes to diseases like cancer. Emerging research highlights its emerging roles in central nervous system (CNS) homeostasis and pathology.

Keywords:
SIRT7deacetylasepost-translational modification

Related Experiment Videos

Last Updated: Mar 29, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.8K

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Neuroscience

Background:

  • Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase localized in the nucleolus.
  • It plays key roles in chromatin regulation, transcription, and stress responses.
  • SIRT7 is implicated in various diseases, including cancer and metabolic disorders.

Purpose of the Study:

  • To review the molecular mechanisms of SIRT7.
  • To summarize its implications in human diseases.
  • To emphasize the emerging roles of SIRT7 in the central nervous system (CNS).

Main Methods:

  • Literature review of SIRT7 research.
  • Analysis of SIRT7's molecular functions.
  • Examination of SIRT7's role in CNS physiology and pathology.

Main Results:

  • SIRT7 is involved in rRNA transcription, histone modification, DNA repair, metabolism, and inflammation.
  • Dysregulation of SIRT7 is linked to CNS pathologies.
  • Evidence suggests SIRT7 influences neuronal homeostasis, glial function, neuroinflammation, and brain injury responses.

Conclusions:

  • SIRT7 has diverse molecular functions with implications for human disease.
  • Its roles in the CNS are increasingly recognized.
  • Further research is needed to fully understand SIRT7 in neurological health and disease.