Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Onyx Migration to the Middle Cerebral Artery Treated by Mechanical Thrombectomy with Subsequent Delayed Migration of Residual Onyx: A Case Report.

Annals of vascular diseases·2026

Same author

Atrial natriuretic peptide can be biomarker for predicting atrial fibrillation in embolic stroke of undetermined source.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same author

Benefits of Regular Intake of Glucolacto-Oligosaccharides on Gut Health in Adults with Low Defecation Frequency: A Randomized, Double-Blind, Placebo-Controlled Study.

Microorganisms·2026

Same author

Design of the Japan Kidney Association-Pemafibrate Intervention for Chronic Kidney Disease patients Study (JKAPI-CKD Study).

Clinical kidney journal·2026

Same author

Pineal Hemorrhage After Alteplase.

Internal medicine (Tokyo, Japan)·2026

Same author

A Case of Hydrophilic Polymer Embolism after Transcatheter Aortic Valve Replacement.

International heart journal·2026

Same journal

Vigorous Physical Activity Mitigates Susceptibility to Obesity Associated with Risk Genotypes of <i>FTO</i> and <i>MC4R</i>, and <i>SREBF1</i> Is Hypermethylated: A Cross-Sectional Pilot Study.

Epigenomes·2026

Same journal

Remodelling of miRNA Regulatory Landscape During West Nile Virus (WNV) Infection.

Epigenomes·2026

Same journal

The Role of Epigenetics in Corneal Fibrosis.

Epigenomes·2026

Same journal

Dual Functionality of miRNAs During HIV Infection: From Viral Genome Suppression to Immune Response Modulation.

Epigenomes·2026

Same journal

Nuclear Transfer Perturbs Genomic Balance.

Epigenomes·2026

Same journal

5mC and 6mA DNA Methylation in the Fungal Kingdom: From Genome Defense to Epigenetic Regulation.

Epigenomes·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

MicroRNA Regulation in Kidney Interstitial Fibrosis.

Hirofumi Sakuma¹, Satoshi Kawaguchi^1,2, Yuya Kobayashi¹

¹Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.

|March 27, 2026

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in chronic kidney disease (CKD) progression. This review explores how miRNAs impact fibrosis and their potential as CKD biomarkers and therapeutic targets.

Keywords:

MicroRNA chronic kidney disease kidney interstitial fibrosis

More Related Videos

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

Related Experiment Videos

Last Updated: Mar 29, 2026

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

Area of Science:

Molecular Biology
Nephrology
Genetics

Background:

MicroRNAs (miRNAs) are crucial for gene regulation and cellular balance.
miRNA dysregulation contributes significantly to tissue injury and chronic kidney disease (CKD) progression.
Interstitial fibrosis, a hallmark of CKD, involves complex cellular changes.

Purpose of the Study:

To review miRNA-mediated regulation in CKD.
To emphasize miRNA roles in fibrotic pathways and cell lineages.
To discuss miRNA potential as CKD biomarkers and therapeutic targets.

Main Methods:

Literature review focusing on miRNA functions in CKD.
Analysis of miRNA involvement in fibroblast activation and cell phenotypic transitions.
Examination of disease-specific miRNA dysregulation in various CKD etiologies.

Main Results:

miRNAs are identified as critical regulators of interstitial fibrosis in CKD.
Dysregulated miRNAs are detected across different CKD causes like diabetic kidney disease and glomerulonephritis.
Specific miRNAs influence fibroblast activation and tubular epithelial cell transitions.

Conclusions:

miRNAs play multifaceted roles in CKD pathogenesis, particularly in fibrosis.
miRNAs represent promising biomarkers for CKD diagnosis and prognosis.
Targeting miRNAs offers a potential therapeutic strategy for managing CKD.