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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Thermosensitive Composite Hydrogels for Sustained Nanoparticle Delivery and Enhanced Wound Healing.

Yiting Qiu1,2, Zhiyun Cheng2, Meiyan Liu2

  • 1College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.

Gels (Basel, Switzerland)
|March 27, 2026
PubMed
Summary

A new injectable hydrogel delivers antioxidant nanoparticles to accelerate wound healing. This advanced wound dressing promotes tissue regeneration and offers sustained drug delivery for improved repair outcomes.

Keywords:
Pluronic F127injectable hydrogelthermosensitive hydrogelwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Wound healing is often hindered by oxidative stress, inflammation, and poor tissue regeneration.
  • Current treatments face challenges in sustained drug delivery and effective tissue repair.

Purpose of the Study:

  • To develop a thermosensitive, injectable composite hydrogel for sustained delivery of sinomenine-gallic acid nanoparticles (SGNPs).
  • To accelerate wound repair by addressing oxidative stress and enhancing tissue regeneration.

Main Methods:

  • A composite hydrogel was formulated using Pluronic F127 (F127), phosphatidylcholine (PC), and L-lysine (Lys).
  • The hydrogel was loaded with SGNPs for sustained release.
  • Characterization included mechanical properties, stability, and microarchitecture analysis.
  • In vitro studies assessed antioxidant activity, keratinocyte behavior, and in vivo efficacy in a murine wound model.

Main Results:

  • The optimized F127-Lys-PC hydrogel demonstrated improved mechanical strength, stability, and injectability with in situ gelation.
  • The hydrogel provided sustained release of SGNPs for up to 24 hours and showed good hemocompatibility.
  • Enhanced antioxidant properties effectively scavenged free radicals and reduced cellular oxidative stress.
  • In vitro tests showed promotion of keratinocyte migration and proliferation.
  • In vivo studies revealed significantly accelerated wound closure, re-epithelialization, angiogenesis, and collagen deposition.

Conclusions:

  • The developed multifunctional thermosensitive hydrogel serves as a promising platform for advanced wound dressings.
  • It effectively integrates sustained drug delivery, antioxidant protection, and tissue regeneration capabilities.
  • This hydrogel holds potential for improving outcomes in wound repair and regeneration.