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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 13, 2026

Hyaluronic-Acid Based Hydrogels for 3-Dimensional Culture of Patient-Derived Glioblastoma Cells
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Next-Generation Hydrogels Integrating Natural Antioxidants and Microbiome Modulators for Improved Cancer Management.

Camelia Munteanu1, Eftimia Prifti1, Larisa Achim1

  • 1Biology Section, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Manastur Street, 400372 Cluj-Napoca, Romania.

Gels (Basel, Switzerland)
|March 27, 2026
PubMed
Summary

This review explores advanced hydrogels designed to deliver natural antioxidants and microbiome modulators for improved cancer therapy, addressing challenges like low bioavailability and targeted delivery.

Keywords:
antioxidantscancerhydrogelsprebioticsprobioticssynbiotics

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Area of Science:

  • Oncology
  • Biomaterials Science
  • Microbiome Research

Background:

  • Cancer is a major global health challenge with treatment limitations due to toxicity and resistance.
  • Gut microbiome dysbiosis and oxidative stress are increasingly recognized as key factors in cancer progression and treatment outcomes.
  • Natural antioxidants (e.g., resveratrol) and microbiome modulators (probiotics, prebiotics, synbiotics) show therapeutic promise but face bioavailability and delivery issues.

Purpose of the Study:

  • To review the design and synthesis of novel multifunctional hydrogels.
  • To explore the use of hydrogels as delivery platforms for natural antioxidants and microbiome modulators in cancer therapy.
  • To address challenges in clinical translation, including targeted delivery and agent stability.

Main Methods:

  • Review of current literature on hydrogel synthesis and functionalization.
  • Analysis of natural antioxidants and microbiome modulators for cancer treatment.
  • Investigation of hydrogel-based delivery systems for enhanced therapeutic efficacy.
  • Discussion of site-specific and controlled release mechanisms.

Main Results:

  • Multifunctional hydrogels offer adaptable platforms for delivering bioactive compounds.
  • Hydrogels can protect sensitive agents like antioxidants and microbiome modulators.
  • Site-specific and controlled delivery via hydrogels can overcome bioavailability and stability limitations.
  • Integration of antioxidants and microbiome modulators within hydrogels presents a promising strategy for cancer therapy.

Conclusions:

  • Next-generation hydrogels are a viable strategy for co-delivering natural antioxidants and microbiome modulators.
  • This approach holds potential for overcoming key challenges in cancer treatment and improving therapeutic outcomes.
  • Further research into hydrogel design and clinical application is warranted for effective cancer therapy.