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Biomechanical Evaluation of CAD/CAM Inlay Restorations Through Experimental Flexural Strength Testing and Finite
Omer Sagsoz1, Mehmet Yildiz2, Hojjat Ghahramanzadeh Asl3
1Department of Restorative Treatment, Faculty of Dentistry, Atatürk University, 25240 Erzurum, Türkiye.
Journal of Functional Biomaterials
|March 27, 2026
Summary
This study compared CAD/CAM inlay materials using mechanical testing and FEA. All materials showed adequate stability, with lithium disilicate offering a larger stress-to-strength margin.
Area of Science:
- Biomaterials science
- Dental materials
- Mechanical engineering
Background:
- Investigating the biomechanical performance of dental restorations is crucial for clinical success.
- Conservative inlay restorations fabricated from various CAD/CAM materials require thorough evaluation.
Purpose of the Study:
- To assess the biomechanical behavior of different CAD/CAM inlay materials.
- To combine experimental flexural strength testing with finite element analysis (FEA) for comprehensive evaluation.
Main Methods:
- Five CAD/CAM materials were tested: feldspathic ceramic, leucite-reinforced ceramic, resin nano-ceramic, polymer-infiltrated ceramic network, and lithium disilicate ceramic.
- Material properties (Young's modulus, Poisson's ratio) were determined experimentally.
- 3D FEA was employed to analyze Von Mises (VM) stress distributions under simulated occlusal loading.
Main Results:
- Maximum VM stresses were inversely related to material elasticity.
- Lithium disilicate ceramic exhibited the highest maximum VM stress (45.571 MPa), while resin nano-ceramic showed the lowest (25.419 MPa).
- All tested VM values remained below the flexural strength (FS) limits of the respective materials.
Conclusions:
- All evaluated CAD/CAM materials demonstrated sufficient mechanical stability under physiological loads.
- Lithium disilicate provided a greater safety margin between stress levels and flexural strength.
- Lower-modulus materials may increase stress transfer to the supporting tooth structures.

