Real-World Vaccination Data Analysis for Three Vaccines Among Individuals Aged 60 and Older in Shanghai, China

Background: Vaccines targeting herpes zoster, influenza, and pneumococcal diseases represent the most effective interventions for reducing morbidity and mortality in individuals aged ≥65 years. This study employs real-world vaccination data for herpes zoster vaccine (HZV), influenza vaccine (InfV), and 23-valent pneumococcal polysaccharide vaccine (PPSV23) among individuals aged ≥60 years in the Pudong New Area of Shanghai, China, from 2020 to 2024, aiming to assess the vaccination coverage for the three vaccines. Methods: Demographic data and vaccination records for HZV, InfV, and PPSV23 were obtained from the Shanghai Immunization Information System. Vaccination coverage, temporal trends, and disparities across different demographic groups and subdistricts or towns were analyzed. Results: From 2020 to 2024, a total of 26,227 doses of HZV, 198,373 doses of InfV, and 102,644 doses of PPSV23 were administered to adults aged ≥60 years in the Pudong New Area of Shanghai, with vaccination coverage of 0.23%, 3.12%, and 1.61%, respectively. HZV coverage peaked in 2023 (0.34%), whereas the highest coverage for InfV (3.94%) and PPSV23 (3.21%) occurred in 2020. The highest vaccination coverage was observed in the 70-74 age group for HZV (0.30%), the 75-79 age group for InfV (5.18%), and the 65-69 age group for PPSV23 (2.15%). Coverage for HZV and InfV was higher among females than males, while PPSV23 coverage was higher among males. Individuals with local household registration had significantly higher coverage for all three vaccines compared to those with non-local registration. The subdistricts or towns with the highest HZV coverage were Jinqiao Town (0.59%), Huamu Subdistrict (0.50%), and Lujiazui Subdistrict (0.34%). For InfV, the highest coverage was observed in Tangqiao Subdistrict (5.50%), Huamu Subdistrict (5.46%), and Lujiazui Subdistrict (4.88%). For PPSV23, the top three were Laogang Town (2.79%), Nicheng Town (2.01%), and Datuan Town (1.93%). Significant spatial clustering was observed for HZV and InfV. Conclusions: Vaccination coverage for HZV, InfV, and PPSV23 among adults aged ≥60 years in the Pudong New Area of Shanghai from 2020 to 2024 was generally low, with evident temporal variations and demographic and spatial disparities. Coverage differed by age group, gender, household registration status, and subdistricts or towns. These findings indicate that future interventions are still needed to increase vaccination coverage among older adults.