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A Rare Submucosal Lesion of the Duodenum
Shuangzhu Yang1, Jingjing Lian2, Aiping Xu2
1Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. shuangzhuyang@163.com.
Journal of Gastrointestinal and Liver Diseases : JGLD
|March 27, 2026
Summary
A rare duodenal submucosal lesion was found in a 68-year-old male. Pathological examination confirmed adenocarcinoma with chronic schistosomiasis after endoscopic full-thickness resection (EFTR).
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Submucosal lesions of the duodenum are uncommon.
- Early detection and accurate diagnosis are crucial for effective management.
Purpose of the Study:
- To report a rare case of duodenal adenocarcinoma presenting as a submucosal lesion.
- To highlight the diagnostic and therapeutic approach.
Main Methods:
- Abdominal MRI identified an incidental duodenal lesion.
- Gastroduodenoscopy and endoscopic ultrasound (EUS) characterized the mass.
- Endoscopic full-thickness resection (EFTR) was performed for diagnosis and treatment.
Main Results:
- A 2 cm mass in the duodenal bulb was identified.
- EUS revealed a hypoechoic mass originating from the muscular layer.
- Pathological examination confirmed adenocarcinoma infiltrating the muscular layer, associated with chronic schistosomiasis.
Conclusions:
- Adenocarcinoma can present as a submucosal duodenal lesion.
- Multimodality imaging and endoscopic resection are valuable tools.
- The association with chronic schistosomiasis warrants further investigation.
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