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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
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Related Experiment Video

Updated: Mar 29, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
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Sepsis After Elective Aortic Root Replacement: An Analysis Using the National Inpatient Sample.

Charles M Quinn1, Sean H Nguyen2, Zachary D Leslie3

  • 1University of Minnesota Medical School, Minneapolis, Minnesota.

The Journal of Surgical Research
|March 27, 2026
PubMed
Summary
This summary is machine-generated.

Sepsis following aortic root replacement (ARR) is linked to weight loss, neurological disorders, and renal failure. However, conditions like thoracic aortic aneurysm and hypertension appear protective against sepsis post-ARR.

Keywords:
aortic root replacementcardiac surgery complicationsnational inpatient sampleperioperative outcomespostoperative sepsisrisk factors

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Area of Science:

  • Cardiovascular Surgery
  • Infectious Disease Epidemiology
  • Health Services Research

Background:

  • Sepsis following aortic root replacement (ARR) presents a significant risk for mortality.
  • Identifying risk factors for post-ARR sepsis is crucial for improving patient outcomes.
  • Previous studies have not thoroughly investigated these specific risk factors.

Purpose of the Study:

  • To identify risk factors associated with sepsis development after elective aortic root replacement.
  • To analyze patient demographics, comorbidities, and health factors influencing sepsis risk.
  • To provide data for targeted interventions to reduce sepsis incidence.

Main Methods:

  • Utilized the National Inpatient Sample (NIS) database from 2017-2022.
  • Included adult patients (≥18 years) undergoing elective ARR.
  • Employed multivariable logistic regression to analyze risk factors.

Main Results:

  • Sepsis occurred in 2.1% of 66,530 patients undergoing elective ARR.
  • Risk factors for sepsis included weight loss/cachexia, neurologic disorders, renal failure, heart failure, liver disease, chronic lung disease, cerebrovascular disease, aortic dissection, and coagulopathy.
  • Protective factors against sepsis included thoracic aortic aneurysm, hypertension, hyperlipidemia, and tobacco use.

Conclusions:

  • Healthcare professionals must recognize sepsis risk factors and protective characteristics post-ARR.
  • Preoperative optimization of modifiable risk factors is recommended for high-risk patients.
  • Awareness of these factors can guide strategies to minimize postoperative sepsis risk.