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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic

Ryo Sekiya1, Masahiko Nakamoto2, Shunsuke Kato3

  • 1Division of Applied Chemistry, Graduate School of Engineering, The University of Osaka, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 27, 2026
PubMed
Summary

Researchers created a programmable transient hydrogel with a tunable lifetime for controlled drug delivery and tissue engineering. This injectable material offers a versatile platform for advanced biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Chemical Engineering

Background:

  • Injectable hydrogels are promising for biomedical applications but often lack controlled degradation.
  • Transient materials that degrade on demand are needed for precise control over drug release and tissue regeneration.

Purpose of the Study:

  • To develop an injectable transient hydrogel with a programmable lifetime.
  • To control the hydrogel's lifespan by tuning its gelation and sol transition pathways.
  • To demonstrate payload release control upon hydrogel degradation.

Main Methods:

  • Introduced closed functional loops for gelation (coordination crosslinking) and sol transition (enzymatic degradation).
  • Engineered a kinetic imbalance between fast gelation and slow sol transition to create a transient state.
  • Programmed hydrogel lifetime from one hour to three months by adjusting pathway kinetics.

Main Results:

  • Successfully developed a transient hydrogel with a programmable lifetime.
  • Demonstrated precise control over hydrogel degradation kinetics.
  • Validated controlled payload release triggered by the hydrogel's sol transition.

Conclusions:

  • The developed transient hydrogel offers tunable degradation for advanced applications.
  • This system has potential applications in patient-specific drug delivery systems.
  • The hydrogel can serve as a scaffold material for tissue engineering.