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Updated: Jun 28, 2026
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3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation
Published on: June 30, 2023
Localized stiffness programming enables tunable spatial control of vascular density in 3D hydrogels
He Li1, Fiona Louis1,2, Oju Jeon3
1Department of Applied Chemistry, Graduate School of Engineering, the University of Osaka, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. m-matsus@chem.eng.osaka-u.ac.jp.
Chemical Communications (Cambridge, England)
|June 26, 2026
Abstract:
We report an in situ light-mediated reinforcement strategy for spatial microvascular patterning. Laser-patterned stiff zones in AlgMA/fibrin hydrogels suppress capillary formation by >81%. A linear stiffness-density relationship (R2 > 0.78) enables predictable engineering of heterogeneous tissue architecture.
