Gastrodin and gastrodigenin: advancing neurogenesis in neurological disease management

Neurogenesis, the creation of new neurons from neural stem cells (NSCs) in the brain, plays a crucial role in neurological diseases when disrupted. Herbal medicine components, especially those with dual applications in disease treatment and food, like those from Gastrodia elata Blume, have gained attention for their ability to influence neurogenesis. Notably, gastrodin and gastrodigenin from this herb influence neurogenesis and affect conditions like Alzheimer's, depression, stroke, and amnesia. Understanding these processes and mechanisms is essential for addressing neurological disorders. We also discuss gastrodin's potential in aiding peripheral nerve regeneration and its therapeutic effects on neurological diseases through neurogenesis regulation. This review offers insights into gastrodin's therapeutic potential, encouraging further research to boost its efficacy in neurological diseases.