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Circulating GDF15 and HbA1c Response to Add-On Exenatide Therapy in Type 2 Diabetes: A Post Hoc Analysis from a

Qi Wu1, Kun Yang1, Xinyue Liao1

  • 1Department of Endocrinology and Metabolism, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University Third Hospital, Beijing 100191, China.

Biomedicines
|March 28, 2026
PubMed
Summary

Higher levels of growth differentiation factor 15 (GDF15) may reduce the effectiveness of exenatide treatment in lowering glycated hemoglobin (HbA1c) for type 2 diabetes patients, especially in those over 35 years old.

Keywords:
glucagon-like peptide-1 agonistsglycated hemoglobingrowth differentiation factor 15type 2 diabetes mellitus

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