Digital Therapy for Male LUTS: Results After Mid- and Longterm Follow-Up

Area of Science:

• Digital Health
• Urology
• Clinical Trials

Background:

• The BEST study evaluated a 12-week digital treatment for male lower urinary tract symptoms (LUTS).
• This report details the long-term outcomes of participants from the BEST randomized controlled trial.

Purpose of the Study:

• To assess the long-term effectiveness of a digital therapeutic program for male LUTS.
• To evaluate symptom changes and quality of life up to 48 weeks post-intervention.

Main Methods:

• A randomized controlled trial involving 237 male patients with LUTS.
• Intervention included pelvic floor training, behavioral therapy, and bladder training via a digital platform.
• Long-term follow-up assessments at 24, 36, and 48 weeks were conducted.

Main Results:

• Significant reductions in International Prostate Symptom Score (IPSS) were observed at all follow-up points compared to baseline.
• Mean IPSS decreased by -6.32 points at 12 weeks and up to -9.56 points at 48 weeks.
• Symptom improvements were sustained after app usage discontinuation, indicating stable long-term effects.

Conclusions:

• A multimodal digital intervention for male LUTS provides rapid and clinically meaningful symptom reduction within 12 weeks.
• The benefits of the digital treatment are consolidated and sustained for up to 48 weeks.
• App-based digital therapeutics offer a viable long-term solution for managing male LUTS.