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Updated: Mar 29, 2026

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Celocentesis: Current Evidence and Future Directions.

Fabiana Cecchini1, Silvia Visentin1, Antonino Giambona2

  • 1Maternal Fetal Medicine Unit, Department of Women's and Children's, School of Medicine, University of Padova, 35131 Padova, Italy.

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|March 28, 2026
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Summary
This summary is machine-generated.

Celocentesis offers the earliest prenatal genetic diagnosis, achieving over 99% accuracy for monogenic conditions in specialized centers. However, further standardization and validation are needed for widespread clinical use.

Keywords:
celocentesiscoelocentesiscoelomic cavity samplingcoelomic fluidcoelomic fluid samplingearly pregnancyfirst-trimester coelomic fluidprenatal diagnosis

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Area of Science:

  • Prenatal Diagnostics
  • Fetal Medicine
  • Genetics

Background:

  • Celocentesis is an early invasive prenatal diagnostic technique.
  • Evidence on its clinical applications, accuracy, and safety is evolving.
  • Modern fetal medicine seeks earlier diagnostic options.

Purpose of the Study:

  • To review current evidence on celocentesis.
  • To focus on clinical applications, diagnostic accuracy, safety, and future perspectives.
  • To assess celocentesis in modern fetal medicine.

Main Methods:

  • A narrative literature review was performed.
  • Databases searched included PubMed and Scopus up to October 2025.
  • Studies with original data on celocentesis were included.

Main Results:

  • Celocentesis has been performed successfully between 6-9 weeks' gestation.
  • Diagnostic success for monogenic conditions exceeds 99% in specialized centers.
  • Miscarriage rates are comparable to early gestational expectations; the procedure is experimental.

Conclusions:

  • Celocentesis is the earliest prenatal genetic diagnostic technique available.
  • Its clinical implementation requires standardization, operator training, and prospective studies.
  • Further evidence is needed regarding safety and diagnostic reliability.