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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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Surgical Necrotising Enterocolitis (S-NEC): Where We Stand Today: A Narrative Review
Maria Manousi1, Dionysios Dellaportas2, Konstantinos Nastos2
1First Department of Pediatric Surgery, "Pan. & Aglaia Kyriakou" Children's Hospital, 11526 Athens, Greece.
Journal of Clinical Medicine
|March 28, 2026
Summary
Surgical necrotising enterocolitis (NEC) in preterm infants requires careful surgical timing and management. Optimizing intervention and post-operative care is crucial for improving outcomes and reducing long-term complications.
Area of Science:
- Neonatal surgery
- Pediatric gastroenterology
- Critical care medicine
Background:
- Necrotising enterocolitis (NEC) poses significant risks to preterm and very-low-birth-weight infants.
- Current evidence guides the transition from medical to surgical management of NEC.
- Improving perioperative and long-term care is essential for this vulnerable population.
Purpose of the Study:
- To review current evidence on surgical management of NEC.
- To guide optimal timing of surgical intervention.
- To enhance perioperative and long-term care strategies.
Main Methods:
- Systematic review of updated evidence.
- Analysis of clinical assessment, laboratory markers, and imaging for surgical indication.
- Evaluation of surgical techniques (laparotomy, peritoneal drainage, laparoscopy).
Main Results:
- Dynamic clinical assessment, inflammation markers, and targeted imaging aid surgical anticipation; pneumoperitoneum is the only absolute indication.
- Optimal surgical timing is critical; delayed surgery worsens outcomes, while very early surgery may indicate severe disease.
- Laparotomy is standard, with peritoneal drainage for unstable infants and laparoscopy as an adjunct.
Conclusions:
- Careful timing of surgical intervention in NEC is paramount.
- Long-term complications necessitate improved predictive tools, imaging, and nutritional support.
- Further research is needed on long-term quality-of-life outcomes.
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