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Related Experiment Video

Updated: Mar 29, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Transcranial Alternating Current Stimulation as an Adjuvant for Nonfluent Aphasia: A Proof-of-Concept Study.

Lynsey M Keator1, Lisa Johnson2, Roger Newman-Norlund3

  • 1Department of Speech-Language Pathology, College of Rehabilitation Sciences, Thomas Jefferson University, 130 South 9th Street, Philadelphia, PA 19107, USA.

Bioengineering (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

High-definition transcranial alternating current stimulation (HD-tACS) combined with speech entrainment improved speech fluency in nonfluent aphasia. This non-invasive brain stimulation approach shows promise for enhancing language rehabilitation in stroke survivors.

Keywords:
nonfluent aphasianoninvasive brain stimulationspeech-language therapytranscranial alternating current stimulation (tACS)

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Area of Science:

  • Neuroscience
  • Speech-Language Pathology
  • Rehabilitation Medicine

Background:

  • Effective rehabilitation for chronic aphasia is crucial.
  • Speech entrainment shows promise for improving speech output in nonfluent aphasia by synchronizing left hemisphere language regions.
  • Transcranial alternating current stimulation (tACS) may enhance functional connectivity by amplifying brain oscillations.

Purpose of the Study:

  • To investigate if high-definition tACS (HD-tACS) paired with speech entrainment can enhance speech fluency in individuals with nonfluent aphasia.
  • To explore the effects of in-phase and anti-phase HD-tACS on speech production.
  • To provide proof-of-concept for HD-tACS as an adjuvant therapy for aphasia.

Main Methods:

  • A double-blind, pseudorandomized study involving 13 individuals with nonfluent aphasia.
  • Application of 1 mA, 7 Hz HD-tACS to left-hemisphere anterior and posterior regions under in-phase, anti-phase, and sham conditions.
  • Paired stimulation with speech entrainment, measuring words produced, errors, and entrainment to the model.

Main Results:

  • Statistically significant differences were observed in word production and entrainment between conditions.
  • In-phase HD-tACS resulted in more words produced compared to the sham condition.
  • In-phase HD-tACS also demonstrated better entrainment to the audiovisual speech model than sham stimulation.

Conclusions:

  • HD-tACS, when paired with speech entrainment, shows promising potential for improving speech production in nonfluent aphasia.
  • These findings support the therapeutic value of non-invasive brain stimulation as an adjunct to traditional speech-language therapy.
  • This approach may offer a novel avenue for stroke survivor rehabilitation.