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Related Experiment Video

Updated: Mar 29, 2026

Murine Prostate Micro-dissection and Surgical Castration
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Calamagrostis arundinacea Extract Mitigates Testosterone Induced Prostatic Hyperplasia in Rats.

Poornima Kumbukgahadeniya1, Eun-Bok Baek1,2, Seung-Hoon Lee1

  • 1Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

Calamagrostis arundinacea (CA) extract reduced prostate weight and key growth factors in a rat model of benign prostatic hyperplasia (BPH). This study suggests CA as a potential phytotherapeutic for BPH management.

Keywords:
Calamagrostis arundinaceaPI3K/Akt mTOR signalingapoptosisbenign prostatic hyperplasia

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Area of Science:

  • Urology
  • Pharmacology
  • Molecular Biology

Background:

  • Benign prostatic hyperplasia (BPH) is an age-related condition characterized by prostate gland enlargement.
  • Calamagrostis arundinacea (CA), a grass species, exhibits anti-inflammatory and antioxidant properties.

Purpose of the Study:

  • To investigate the efficacy of CA extract in mitigating testosterone-induced BPH in a rat model.
  • To explore the molecular mechanisms underlying CA's effects on prostate growth.

Main Methods:

  • Rats were administered testosterone propionate (TP) to induce BPH.
  • CA extract was orally administered concurrently with TP.
  • Prostate weight, hormone levels (testosterone, DHT), cell proliferation (PCNA), apoptosis (TUNEL), gene expression (Igf-2, Tgf-β, Vegf), and signaling pathways (PI3K/Akt/mTOR) were analyzed.

Main Results:

  • CA supplementation significantly reduced prostate weight and circulating testosterone and dihydrotestosterone (DHT) levels.
  • CA mitigated prostatic hyperplasia, reduced PCNA expression, and increased apoptosis.
  • CA downregulated Igf-2, Tgf-β, and Vegf gene expression and inhibited the PI3K/Akt/mTOR pathway.

Conclusions:

  • CA extract effectively alleviates testosterone-induced BPH in rats.
  • CA exerts its effects by suppressing growth-related signaling pathways and inducing apoptosis.
  • CA demonstrates potential as a phytotherapeutic agent for managing BPH.