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HFE p.C282Y Polymorphism and Risk of Metabolic Syndrome Components: Systematic Review and Meta-Analysis.
Dana Kaldarkhan1, Gulnaz Nuskabayeva1, Nursultan Nurdinov1
1Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan 160000, Kazakhstan.
Medicina (Kaunas, Lithuania)
|March 28, 2026
Summary
This meta-analysis found no significant link between the HFE p.C282Y gene variant and metabolic syndrome components like diabetes or hypertension. The HFE polymorphism does not appear to influence key metabolic syndrome risk factors.
Area of Science:
- Genetics
- Metabolic Disorders
- Cardiovascular Health
Background:
- Metabolic syndrome increases risks for diabetes and cardiovascular disease.
- Iron metabolism alterations, particularly overload, may contribute to insulin resistance and hypertension.
- The HFE p.C282Y polymorphism's role in metabolic syndrome is unclear due to inconsistent study findings.
Purpose of the Study:
- To conduct a comprehensive meta-analysis on the association between the HFE p.C282Y polymorphism and metabolic syndrome components.
- To synthesize evidence regarding HFE p.C282Y and its potential impact on diabetes, hypertension, obesity, triglycerides, and HDL cholesterol.
Main Methods:
- Systematic literature search of PubMed, Scopus, and Web of Science.
- Inclusion of observational studies comparing HFE p.C282Y carriers and non-carriers.
- Meta-analysis of data on diabetes, hypertension, abdominal obesity, triglyceride levels, and HDL cholesterol.
Main Results:
- Pooled analysis of 17 studies revealed no significant association between HFE p.C282Y and diabetes.
- No significant association was found for hypertension, triglyceride levels, or HDL cholesterol levels.
- Analyses under codominant and homozygous models showed no statistically significant links.
Conclusions:
- This meta-analysis concludes there is no statistically significant association between the HFE p.C282Y polymorphism and metabolic syndrome components.
- The findings suggest the HFE p.C282Y variant does not play a significant role in the development of common metabolic abnormalities studied.
Keywords:
abdominal obesitydiabeteshemochromatosishigh-density lipoprotein cholesterolhypertensionmetabolic syndrometriglyceridesMore Related Videos
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