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Updated: Mar 29, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

A Novel Fluorescence-Triggered Auditory Feedback Photosensor for Precision Lymph Node Mapping.

Kicheol Yoon^1,2,3,4,5, Hyunjun Son^2,3, Hari Kang⁶

¹Division of Medical Oncology & Gachon Biomedical Convergence Institute, Gachon University Gil Medical Center, Incheon 21565, Republic of Korea.

Sensors (Basel, Switzerland)

|March 28, 2026

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This summary is machine-generated.

This study introduces a fluorescence-based method using indocyanine green (ICG) to rapidly detect lymph nodes (LNs) during cancer surgery. An audible alarm signals LN identification, potentially reducing surgical time and improving cancer staging.

Area of Science:

Oncology
Surgical Innovation
Medical Imaging

Background:

Accurate lymph node (LN) examination is crucial for cancer staging and treatment.
Metastasis detection in LNs significantly impacts patient prognosis.
Fluorescence imaging offers a method for real-time LN visualization in surgery.

Purpose of the Study:

To develop and evaluate a fluorescence-based system for rapid intraoperative lymph node detection.
To improve the accuracy and efficiency of lymph node assessment in cancer surgery.
To reduce surgical time and enhance the precision of metastasis detection.

Main Methods:

Cancer tissue and lymph nodes are stained with indocyanine green (ICG).
Light-emitting diodes (LEDs) induce fluorescence in stained lymph nodes.

Keywords:

LED alarm fluorescence emission guided monitoring lymph node detection photo sensor

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Last Updated: Mar 29, 2026

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A photosensor and speaker system detect fluorescence and emit an audible alarm.

Filters are employed to minimize false alarms.

Main Results:

The system successfully detected lymph nodes, triggering an audible alarm.
Fluorescence imaging verified lymph node identification in clinical trials.
Indocyanine green (ICG) also stained blood vessels, presenting a challenge for specificity.

Conclusions:

Fluorescence detection via photosensors enables rapid lymph node identification.
An audible alarm confirms detection, potentially shortening surgical duration.
This technique shows promise for widespread use in oncologic surgery, with AI potentially improving accuracy.