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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Transition-Metal-Catalyzed Asymmetric Synthesis of Bicyclo[3.3.1]nonane Frameworks

Bing Liu1, Tingyuan Zheng1, Jiahui Cheng1

  • 1Research Institute for Doping Control, Shanghai University of Sport, Shanghai, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 28, 2026
PubMed
Summary

Transition-metal catalysis offers efficient and selective routes to bicyclo[3.3.1]nonanes, crucial scaffolds in drug discovery. This review highlights advances in palladium, rhodium, and copper-catalyzed asymmetric synthesis for these complex structures.

Keywords:
asymmetric synthesisbicyclo[3.3.1]nonanecyclizationtransition metal catalysis

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