Related Experiment Video
Updated: Mar 30, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
Low-Dose Oral Minoxidil Improves Hairline and Eyebrow Coverage in Frontal Fibrosing Alopecia: A Prospective Study
Diego Henrique Morais Silva1, Mercedes Cristina Mongelli Martin Paro2, Gustavo Baptista de Almeida Faro2
1Hospital do Servidor Público Municipal de São Paulo, Castro Alves Street, n° 60, Aclimação, SP, Brazil. dhenriquems@gmail.com.
Introduction:
Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia that commonly presents with frontotemporal hairline recession and eyebrow loss. While most treatments aim to control inflammation and stop disease progression, low-dose oral minoxidil (LDOM) has been proposed to enhance coverage of remaining hairs and improve cosmetic outcomes.
Methods:
In this prospective study, adult women with biopsy-proven FFA received oral minoxidil 1 mg/day for 6 months. Standardized photographs and trichoscopy images were obtained at baseline and after treatment and blindly evaluated by two independent experts using a 5-point scale (-2 to +2). Safety was monitored through clinical and laboratory assessments. All patients gave consent for use of their photographs.
Results:
A total of 11 women were included (mean age 58.2 years); one discontinued treatment due to a transient ischemic attack. Among 10 completers, all showed improvement in at least one area, with increased anterior hairline coverage in nine and eyebrow improvement in four of eight evaluated patients. Mild hypertrichosis occurred in five cases.
Conclusions:
LDOM improved anterior hairline and eyebrow coverage in women with FFA and was generally well-tolerated. Protocol Number: HSPM58444422.0.0000.5442.
Related Concept Videos
Antihypertensive Drugs: Vasodilators
Multipotency and Niche of Bulge Stem Cell
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Accessory Structures of the Skin: Hair Growth and Types

