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Updated: Mar 30, 2026

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Epigenomics and Epigenetics in Heart Failure with Preserved Ejection Fraction
1Division of Cardiology, Department of Medicine, University of British Columbia, 9th Floor 2775 Laurel Street, Vancouver, British Colombia V5Z 1M9, Canada.
Abstract:
Heart failure with preserved ejection fraction is a complex entity and includes a constellation of different subtypes with different and pathophysiologic mechanisms include those related to myocardial fibrosis, obesity, metabolic disturbances, inflammation, oxidative stress, epicardial fat, and aging. Epigenomic/epigenetic changes can operate on each of these mechanisms through the fundamental aspects of epigenomic or epigenetic processes of DNA methylation, ATP-dependent chromatin remodeling, histone modifications (acetylation, sumoylation, and O-GlcNAcylation), and microRNAs.
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