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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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Functions of the Gut Microbiota01:18

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The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
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The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
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Lactobacillus acidophilus Postbiotics Differentially Modulate Nutrient Sensing, Intestinal Barrier Integrity, and

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Comprehensive Physiology
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Lactobacillus acidophilus-derived postbiotics significantly improved broiler chicken growth and gut health. These findings support postbiotics as a sustainable alternative to antibiotic growth promoters (AGPs) in poultry farming.

Keywords:
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Area of Science:

  • Animal Science
  • Microbiology
  • Immunology

Background:

  • Global restrictions on antibiotic growth promoters (AGPs) necessitate sustainable alternatives for poultry. Postbiotics offer functional stability and immunometabolic benefits.
  • Lactobacillus acidophilus-derived postbiotics are explored for their potential to enhance poultry growth performance and intestinal health.

Purpose of the Study:

  • To evaluate the effects of Lactobacillus acidophilus-derived postbiotics on broiler chickens.
  • Assess impacts on growth performance, nutrient sensing, intestinal barrier integrity, immune response, antioxidant status, and gut microbiota.

Main Methods:

  • 400-day-old broilers were assigned to four dietary treatments with graded postbiotic supplementation (0.0%, 0.5%, 1.0%, 2.0%) for 42 days.
  • Evaluated growth performance, immune/antioxidant indices, histomorphology (intestinal/hepatic), gene expression, and cecal microbial composition.

Main Results:

  • 1.0% and 2.0% postbiotic supplementation significantly increased average daily gain and feed intake.
  • Enhanced systemic immunity (serum IgA, IgG, IgM), improved intestinal morphology (villus height), and reduced hepatic inflammation.
  • Upregulated nutrient transporters (SGLT1, PepT1), tight junction protein ZO-1, antioxidant enzyme GPX1; downregulated IL-1β and IL-6; increased beneficial gut bacteria.

Conclusions:

  • L. acidophilus-derived postbiotics improve broiler performance by enhancing nutrient absorption, antioxidant capacity, and immune regulation.
  • Postbiotics support intestinal barrier function and modulate gut microbiota, positioning them as a viable sustainable alternative to AGPs.