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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: Mar 31, 2026

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.

Tommaso Curiale¹, Marie Celine Lefevre¹, Alessio Carmignani¹

¹Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Pontedera, Italy.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|March 30, 2026

Summary

This summary is machine-generated.

Recent advances in active nanomaterials offer precise neuromodulation via remotely controlled nanotransducers. These smart nanotechnologies pave the way for tailored therapies for neurological and psychiatric disorders.

Keywords:

nanosensors neuromodulation organic nanomaterials smart nanotechnologies stimuli‐responsive nanoparticles

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Area of Science:

Nanotechnology
Neuroscience
Biomedical Engineering

Background:

Neuromodulation techniques are crucial for understanding and treating brain disorders.
Current methods often lack spatiotemporal precision and can be invasive.

Purpose of the Study:

To review recent advancements in active nanomaterials for precise neuromodulation.
To explore the potential of these nanotechnologies for clinical translation in brain disorders.

Main Methods:

Focus on stimuli-responsive nanomaterials and remotely controlled nanotransducers.
Examination of energy transduction mechanisms in nanoparticle-assisted neuromodulation.
Highlighting nanosensors for monitoring neural activity.

Main Results:

Active nanomaterials enable spatiotemporally precise brain interfacing.
Nanosensors provide high-resolution monitoring of bioelectrical and neurochemical activity.
Strategies for targeting glial function and crossing the blood-brain barrier are emerging.

Conclusions:

Smart nanotechnologies are foundational for next-generation precision brain interfacing.
Potential for patient-tailored therapeutic solutions for neurological and psychiatric disorders.
Key challenges for clinical translation include safety, biointegration, and regulation.