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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Site-Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene-Functionalized Monolayers
Boone W Evans1, Kenneth N Hipp1, William D Lambert1
1Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
None:
We report the first example of self-assembled monolayers (SAMs) incorporating a cyclobutene-substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron-demand Diels-Alder (IEDDA) cycloadditions. Mixed SAMs incorporating both cyclobutene- and azide-substituted alkane thiols undergo controlled bisfunctionalization through either sequential or simultaneous performance of IEDDA and copper-assisted alkyne/azide cycloaddition (CuAAC) ligations.
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