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Published on: June 26, 2018
Coumarin Dimers From Hydrangea davidii and Their Antimalarial Activities
Wan-Xian Qi1,2, Wei-Juan Zu1,2, Gang Li1,2
1Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali University, Dali, People's Republic of China.
Abstract:
Two new coumarin dimers, hydradavins A and B (1 and 2), along with a coumarin-phenylpropanoid adduct (3), were isolated from the 95% EtOH extract of roots and stems of Hydrangea davidii. Their structures were determined by comprehensive analyses of the spectroscopic data and physicochemical properties. Hydradavins A and B (1 and 2) are the first examples of coumarin dimers from the genus Hydrangea. In addition, compound 3 exhibited significant in vitro antimalarial activity with IC50 value of 1.7 ± 0.1 μM.
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