Post-Translational Modifications of Histones and Non-Histones in Liver Disease and Traditional Chinese Medicine

Zhuohua Xie1, Yanting Deng2, Xinru Zhang1

  • 1Department of Pharmacy, Liuzhou People's Hospital, Liuzhou, Guangxi, People's Republic of China.

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Histone Modification02:32

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Histone Modification02:32

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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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