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Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Mar 31, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Endophthalmitis Caused by α-Streptococcal Following Intravitreal Ranibizumab Biosimilar Administration Using a

Kengo Utsunomiya¹, Yoichi Sakurada¹, Hiroshi Kasai¹

¹Department of Ophthalmology, University of Yamanashi, Chūō, JPN.

|March 30, 2026

Summary

A rare case of endophthalmitis caused by alpha-streptococcal infection after intravitreal ranibizumab biosimilar injection is presented. Urgent vitrectomy with antibiotic irrigation led to significant visual recovery, highlighting effective treatment for this vision-threatening complication.

Area of Science:

Ophthalmology
Infectious Diseases

Background:

Endophthalmitis is a serious complication following intravitreal injections, potentially leading to vision loss.

Keywords:

endophthalmitis intravitreal injection pre-filled syringe vascular endothelial growth factor α-streptococcus

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Intravitreal injections, including those with biosimilar ranibizumab, carry a risk of microbial contamination and subsequent infection.

Alpha-streptococcal infections are a rare but significant cause of post-injection endophthalmitis.