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Updated: Mar 31, 2026
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Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
Published on: May 9, 2016
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Marine collagen for regenerative medicine: Structure-function advantages, limitations, and translational pathways
Rui Yuan1,2,3, Wenhui Huang1,2,3, Heng Liu1,4
1Human Organ Physiopathology Emulation System, State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Bioactive Materials
|March 30, 2026
Summary
Marine collagen offers superior biocompatibility and low immunogenicity for regenerative medicine. Advanced manufacturing enhances its use in scaffolds and wound healing, paving the way for clinical translation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Marine collagen presents unique structural and biological advantages over mammalian collagen.
- It offers high biocompatibility, low immunogenicity, and antibacterial properties.
- Sustainable sourcing eliminates zoonotic risks, ensuring a reliable supply chain.
Purpose of the Study:
- To analyze the structure-function relationships of marine collagen for regenerative applications.
- To evaluate advanced manufacturing technologies for utilizing marine collagen.
- To outline pathways for clinical translation and address associated challenges.
Main Methods:
- Comprehensive literature review focusing on marine collagen properties and applications.
- Analysis of structure-function relationships in marine collagen.
- Evaluation of advanced manufacturing techniques like 3D bioprinting and electrospinning.
- Assessment of clinical translation challenges, including scalability and regulatory compliance.
Main Results:
- Marine collagen's distinct amino acid profile enhances biocompatibility and reduces immune response.
- Advanced manufacturing enables the creation of optimized cartilage scaffolds and immunomodulatory wound matrices.
- Key pathways for clinical translation are identified, alongside strategies to overcome scalability and stability hurdles.
Conclusions:
- Marine collagen is a superior alternative to mammalian collagen in regenerative medicine.
- Integration of marine collagen with advanced manufacturing offers transformative therapeutic potential.
- This review provides a framework for the clinical translation of marine collagen, positioning it as a key platform material for future therapies.
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