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Microbiome of the Eye01:22

Microbiome of the Eye

37
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
37

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Microbial Keratitis in Southern Arizona.

Ahmed Abdelhady1,2, Jonathan Han1, Robert Wu3

  • 1Department of Ophthalmology and Vision Science, University of Arizona-Tucson, Tucson, Arizona, USA.

Ophthalmic Research
|March 30, 2026
PubMed
Summary
This summary is machine-generated.

Microbial keratitis in Southern Arizona disproportionately affects unemployed, homeless, and drug-using individuals. Safe contact lens practices are crucial to prevent this vision-threatening infection.

Keywords:
CorneaKeratitisMicrobial keratitisSouthwest regionUlcer

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Microbial keratitis data is scarce in Southwestern US, particularly Southern Arizona.
  • Understanding local demographic and causative factors is vital for targeted interventions.
  • Previous studies lack focus on socioeconomic and behavioral associations.

Purpose of the Study:

  • To investigate demographic, social, and clinical factors associated with microbial keratitis in Southern Arizona.
  • To identify common microbial pathogens causing keratitis in the region.
  • To inform preventative strategies and public health initiatives.

Main Methods:

  • Retrospective chart review of microbial keratitis cases (>17 years old) from 2017-2022.
  • Analysis of patient demographics, ocular factors, and microbial culture results.
  • Comparison of demographic findings with US Census data using Fisher's exact tests.

Main Results:

  • 272 eyes from 268 patients reviewed; unemployment (50.4%) and homelessness (8.2%) were overrepresented.
  • Drug use (22.4%), contact lens wear (33.1%), and ocular trauma (14.7%) were significant associated factors.
  • Bacterial pathogens dominated (96.5%), with Staphylococcus epidermidis and Pseudomonas aeruginosa being most common; fungal isolates were rare (3.4%).

Conclusions:

  • Microbial keratitis in Southern Arizona is strongly linked to socioeconomic factors like unemployment, homelessness, and drug use.
  • Contact lens wear, especially overnight use, is a prevalent risk factor, necessitating patient education on safe practices.
  • Findings highlight the need for societal interventions and evaluation of these risk factors in other communities to reduce the burden of microbial keratitis.