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    This study introduces the Wavelet-Driven Spatial Frequency Mamba Network (WDSFM-Net) for precise spine segmentation in MRI. The novel WDSFM-Net enhances anatomical detail and global context, outperforming existing methods.

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    Area of Science:

    • Medical Imaging
    • Artificial Intelligence
    • Biomedical Engineering

    Background:

    • Accurate spine segmentation is vital for diagnosing and treating spinal diseases.
    • Mamba-based methods show promise in medical image segmentation but struggle with fine spinal structures and global dependencies.
    • Existing frequency-enhanced methods can lose spatial localization, hindering detailed anatomical analysis.

    Purpose of the Study:

    • To develop an advanced deep learning network for accurate spine segmentation in MRI.
    • To address limitations of existing Mamba and frequency-enhanced methods in capturing spinal anatomy.
    • To improve diagnostic capabilities for spinal diseases through enhanced segmentation.

    Main Methods:

    • Proposed the Wavelet-Driven Spatial Frequency Mamba Network (WDSFM-Net) integrating Discrete Wavelet Transform (DWT) with Mamba.
    • Introduced Spatial-Frequency Mamba Block (SFMB) to capture global context and local details across frequency subbands.
    • Developed Global Strip Pooling Attention (GSPA) and Multi-Scale Attention Enhancement (MSAE) modules for spinal morphology and scale variations.
    • Implemented a Dual-Domain Loss (DDL) function for robust training in both spatial and frequency domains.

    Main Results:

    • WDSFM-Net demonstrated superior performance on two public spine MRI datasets (Spider and MRSpine).
    • Achieved average Dice similarity coefficients of 0.8885 on the Spider dataset and 0.8669 on the MRSpine dataset.
    • Outperformed other state-of-the-art methods in spine segmentation accuracy.

    Conclusions:

    • WDSFM-Net effectively addresses the limitations of previous methods for spine segmentation.
    • The proposed network accurately captures both global context and fine anatomical details of the spine.
    • This advancement holds significant potential for improving the diagnosis and treatment of spinal conditions.