Short Dynamic 68 GA-PSMA PET Reconstruction to Differentiate Urinary Excretion From Extra-urinary Uptakes With...

Area of Science:

• Nuclear Medicine
• Radiology
• Oncology

Background:

• Large Field of View (LAFOV) PET scanners offer high sensitivity for improved image quality.
• Distinguishing pathological uptake from physiological urinary excretion in 68GA-PSMA-11 PET/CT can be challenging.
• Accurate localization of prostate cancer metastases is crucial for effective treatment planning.

Purpose of the Study:

• To evaluate the added value of dynamic 68GA-PSMA-11 PET/CT acquisitions using an LAFOV PET system.
• To assess the utility of dynamic imaging in differentiating pathological uptakes from urinary excretion.
• To demonstrate the feasibility of dynamic reconstruction for improved diagnostic discrimination.

Main Methods:

• A case report detailing the use of a LAFOV PET system for 68GA-PSMA-11 PET/CT.
• Performance of a single-bed, 4-minute list-mode acquisition.
• Reconstruction of the dynamic acquisition into four 1-minute frames to visualize urinary excretion over time.

Main Results:

• Dynamic visualization of 68GA-PSMA-11 urinary ureteral excretion was achieved.
• The method allowed for improved discrimination between pathological uptakes (e.g., lymph nodes) and physiological urinary uptake.
• The technique required no additional acquisition time or radiation exposure.

Conclusions:

• Dynamic 68GA-PSMA-11 PET/CT acquisitions on LAFOV PET systems are valuable for distinguishing pathological from physiological urinary uptake.
• This technique enhances diagnostic accuracy in identifying metastatic prostate cancer.
• The method is easily implementable in clinical practice.