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Palmitic and oleic acids in type 2 diabetes mellitus

Xavier Palomer1, Ricardo Rodríguez-Calvo2, Marta Tajes3

  • 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona 08028, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona 08028, Spain; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Madrid 28029, Spain; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat 08950, Spain.

Trends in Endocrinology and Metabolism: TEM
|March 30, 2026
PubMed
Summary

Palmitic acid may worsen insulin resistance and type 2 diabetes (T2DM), while oleic acid might offer protection. This review explores their molecular mechanisms and future research directions for T2DM dietary fatty acid metabolism.

Keywords:
ROSTLR4ceramidediacylglycerolinflammationlipotoxicity

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