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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

[Annual progress in chemotherapy for tuberculosis in 2025].

M S Wang¹, H Y Li², Y Xiong¹

¹Public Health Clinical Center Affiliated to Shandong University, Jinan 250013, China.

Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases

|March 30, 2026

Summary

Advances in tuberculosis (TB) treatment are shifting towards shorter, all-oral, and individualized regimens. New drugs and optimized combinations show high efficacy and safety, paving the way for precision TB chemotherapy.

Area of Science:

Infectious Diseases
Pharmacology
Public Health

Background:

Substantial progress in anti-tuberculosis (TB) drug development and treatment strategies.
Transition towards shorter-course, all-oral, and individualized TB chemotherapy regimens.
Recent advancements in both preventive and therapeutic TB interventions.

Purpose of the Study:

To systematically review advances in TB chemotherapy research from October 2024 to September 2025.
To emphasize progress in preventive therapy, treatment of drug-susceptible and rifampicin-resistant TB.
To inform China's TB control strategies by translating emerging evidence into clinical practice.

Main Methods:

Review of recent clinical trials and real-world studies on TB preventive therapies and treatments.
Analysis of novel anti-TB agents and optimized combination regimens.
Synthesis of data on adherence, safety, efficacy, and cure rates.

Main Results:

Short-course rifamycin-containing preventive therapies (1HP, 3HP, 4R) show high adherence and safety.
Fluoroquinolone-based regimens support treatment for contacts of multidrug-resistant TB.
Novel agents (Telacebec, Quabodepistat, Sutezolid, Delpazolid) and regimens (BPaL/BPaLM, 4-month rifapentine-moxifloxacin) demonstrate high cure rates and tolerability.
All-oral regimens offer feasible alternatives with comparable efficacy across resistance patterns.

Conclusions:

TB chemotherapy is evolving from uniform courses to precision-stratified and individualized management.
Future research will focus on new mechanisms, precision pharmacology, safety in special populations, and real-world evidence.
These developments provide a foundation for globally harmonized yet locally adapted TB control strategies.

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