Related Experiment Video

Updated: Apr 1, 2026

Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound
10:09

Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound

Published on: August 4, 2022

3.8K

Albuminuria and Carotid Atherosclerosis in Type 1 Diabetes Evaluated Using Three-Dimensional Vascular Ultrasound

Luis F Ferreira-Divino1, Christina G Poulsen1, Viktor Rotbain Curovic1

  • 1Steno Diabetes Center Copenhagen, Herlev, Denmark.

Diabetes, Obesity & Metabolism
|March 31, 2026
PubMed

Insights

Individuals with type 1 diabetes exhibit increased carotid plaque volume compared to healthy individuals. Higher albuminuria levels correlate with greater carotid plaque burden in type 1 diabetes patients.

Area of Science:

  • Cardiovascular Medicine
  • Diabetology
  • Vascular Ultrasound Imaging

Background:

  • Albuminuria signifies elevated cardiovascular disease (CVD) and mortality risk in type 1 diabetes.
  • Carotid atherosclerosis is a key indicator of CVD risk.

Purpose of the Study:

  • To compare carotid atherosclerosis between type 1 diabetes patients and healthy controls.
  • To evaluate the association between albuminuria and carotid atherosclerosis in type 1 diabetes.

Main Methods:

  • A cross-sectional study involving 290 type 1 diabetes patients and 60 healthy controls.
  • Three-dimensional vascular ultrasound (3DVUS) measured carotid total plaque volume (TPV); two-dimensional vascular ultrasound (2DVUS) measured carotid maximal plaque thickness (cPTmax).
  • Ordinal logistic regression analyzed TPV and cPTmax in relation to albuminuria categories.

Main Results:

  • Type 1 diabetes patients showed significantly higher median TPV (28 mm³ vs. 9 mm³) and cPTmax (14 mm vs. 11 mm) than controls.
  • Higher albuminuria levels in type 1 diabetes patients were independently associated with increased TPV and cPTmax.
  • Severely increased albuminuria was linked to higher TPV compared to normal albuminuria.

Conclusions:

  • Type 1 diabetes patients have greater carotid plaque volume than healthy individuals, irrespective of other risk factors.
  • Elevated albuminuria levels are directly associated with increased carotid plaque burden in type 1 diabetes.
  • Vascular ultrasound effectively quantifies atherosclerosis in type 1 diabetes and its relation to albuminuria.
Abstract

Keywords:
cardiovascular diseasediabetes complicationsdiabetic nephropathymacrovascular diseasetype 1 diabetes

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.9K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.6K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
669
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
474
Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
2.9K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
750