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The Progress of Tertiary Lymphoid Structures in Gastric Cancer
Fei Li1, Wenjing Gong1, Aina Liu1
1Department of Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
Immunological Investigations
|March 31, 2026
Summary
Tertiary lymphoid structures (TLSs) in gastric cancer are linked to better treatment outcomes and prognosis. Understanding TLS formation and function is key for developing new immunotherapies and improving patient survival.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Tertiary lymphoid structures (TLSs), or ectopic lymphoid aggregates, are key components of the tumor microenvironment.
- In gastric cancer, TLS characteristics like presence, composition, size, density, and maturity significantly impact treatment response and prognosis.
Purpose of the Study:
- To review the formation of TLSs in gastric cancer.
- To evaluate the potential of TLSs as prognostic biomarkers and therapeutic targets in gastric cancer.
Main Methods:
- A comprehensive literature review was performed.
- Analysis focused on the biological characteristics, formation mechanisms, and clinical relevance of TLSs in gastric cancer.
Main Results:
- TLSs are associated with enhanced immune responses, improved therapeutic outcomes, and favorable prognosis in gastric cancer.
- TLS structural features and maturation status influence their role in antitumor immunity.
Conclusions:
- TLSs show promise as prognostic indicators and immunotherapy targets for gastric cancer.
- Further research is needed to elucidate TLS mechanisms and clinical applications for advanced gastric cancer patients.
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