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Updated: Apr 1, 2026

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification
Published on: October 11, 2024
[Adeno-associated virus-mediated gene therapy for genetic epilepsy: prospects and challenges]
Bo Sun1, Xiao-Le Wang1, Jing Peng1
1Children's Medical Center, Xiangya Hospital of Central South University/Clinical Research Center for Children's Neurodevelopmental Disabilities of Hunan Province, Changsha 410008, China.
Abstract:
With the development and launch of anti-seizure medications, some genetic epilepsies have precision treatments; however, many patients remain drug-resistant, which severely affects quality of life and overall health. Advances in gene therapy have changed traditional diagnostic and therapeutic approaches for hereditary diseases, improved diagnostic accuracy, and brought new hope to patients. Adeno-associated virus is a leading vector in gene therapy and is widely used. This review summarizes the application prospects and challenges of adeno-associated virus-mediated gene therapy for genetic epilepsy to inform clinical practice.
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