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Updated: Apr 1, 2026
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
NIR-II Photoacoustic-Cavitation Boosted Metabolic Reprogramming Regulation Toward the Localized TNBC Growth
Leilei Zhang1, Haoheng Bai1, Weiqi Sun1
1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, People's Republic of China.
This study introduces a novel near-infrared dual windows photoacoustic cavitation strategy for triple-negative breast cancer (TNBC) treatment. The approach enhances oxidative stress and disrupts metabolism, offering effective tumor suppression.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Triple-negative breast cancer (TNBC) presents treatment challenges due to limited light penetration and hypoxic microenvironments.
- Traditional phototherapeutics are often insufficient for effective TNBC management.
- Novel strategies are needed to overcome TNBC's unique biological features.
Purpose of the Study:
- To develop a near-infrared dual windows (NIR-II) photoacoustic (PA) cavitation-based strategy for TNBC treatment.
- To amplify oxidative stress and induce metabolic disruption in TNBC cells.
- To achieve effective tumor suppression using a multimodal approach.
Main Methods:
- Fabrication of a nanoagent (DTG) integrating photomechanical damage, cavitation-promoted oxidative damage, and glucose oxidase (GOx).
- Application of NIR-II pulsed laser (PL) irradiation to induce PA cavitation and generate shock waves.
- GOx-mediated glucose depletion to block glycolysis and ATP production, generating reactive oxygen species.
Main Results:
- PA cavitation induced mechanical injury and amplified oxidative damage in TNBC cells.
- GOx-mediated glucose depletion disrupted cellular metabolism and generated toxic reactive oxygen species (ROS).
- The nanoagent produced strong NIR-II PA signals for high-resolution deep-tissue imaging and therapeutic guidance.
Conclusions:
- The developed multimodal strategy effectively suppresses TNBC tumors.
- This approach offers an oxygen-independent therapeutic effect, overcoming tumor hypoxia limitations.
- The strategy shows potential as a potent therapeutic candidate for TNBC management.
