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Updated: Apr 2, 2026
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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Superficial CIC::DUX4 Sarcoma With Focal WT1 Expression: Histomorphologic Clues and Immunohistochemical Pitfalls
Janice Jiang1, Brandon Say2, Ryanne Brown3
1Department of Dermatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Journal of Cutaneous Pathology
|April 1, 2026
Summary
CIC::DUX4 sarcoma (CDS) is a rare tumor. Genomic profiling aided diagnosis in a challenging case with an atypical immunophenotype, underscoring difficulties in diagnosing small round blue cell sarcomas.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- CIC::DUX4 sarcoma (CDS) is a rare tumor.
- It is often included in the differential diagnosis of small round blue cell sarcomas.
- Typically, CDS is EWSR1-negative with strong nuclear WT1 and ETV4 expression.
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