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Updated: Apr 2, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
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PTP1B Inhibitors for Type 2 Diabetes: From Natural Products, Synthetic Inhibitors, and Multi-Target Drug Design

Pallavi Joshi1, Avijit Mazumder1, Bhavani Pentela1

  • 1Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park- II, Greater Noida, 201306 Uttar Pradesh. India.

Current Drug Targets
|April 1, 2026
PubMed
Summary

Protein Tyrosine Phosphatase 1B (PTP1B) inhibitors are crucial for treating type 2 diabetes and other diseases. New strategies like PROTAC degraders and multi-target inhibitors are being developed to overcome past challenges in drug discovery.

Keywords:
Diabetes mellitusPTP1Bmarine-derived inhibitorsnatural productsplant-derived compoundstherapeutic strategies.

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