In Vitro Antimicrobial Activity and In Vivo Intestinal Barrier Regulation by Commiphora leptophloeos Bark Extract in
Stphannie Jamyla de Araújo Barbosa1, Renato Dantas-Medeiros2, Susana Barbosa Ribeiro1
1Postgraduate Program in Pharmaceutical Science, Federal University of Rio Grande Norte, Natal, Brazil.
Chemistry & Biodiversity
|April 1, 2026
Summary
Commiphora leptophloeos stem bark extract (HECL) shows antimicrobial properties and protects against chemotherapy-induced intestinal injury. This natural compound supports gut health and may aid in managing gastrointestinal disorders.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Gastroenterology
Background:
- Commiphora leptophloeos (HECL) is traditionally used for gastrointestinal issues.
- Limited scientific data exists on HECL's chemical profile and effects on chemotherapy-induced intestinal injury.
Purpose of the Study:
- To investigate the phytochemical composition of HECL.
- To evaluate the antimicrobial activity of HECL.
- To assess the in vivo protective effects of HECL against 5-fluorouracil (5-FU)-induced intestinal mucositis.
Main Methods:
- Phytochemical analysis using mass spectrometry.
- Antimicrobial screening against 90 bacterial strains.
- In vivo study in mice using 5-FU to induce mucositis, followed by HECL treatment.
Main Results:
- Identified 21 metabolites in HECL, primarily procyanidins and flavonoids.
- HECL exhibited selective antimicrobial activity against Gram-positive bacteria.
- HECL treatment preserved intestinal architecture, reduced IL-6, increased MUC-2 expression, and modulated oxidative stress markers.
Conclusions:
- HECL possesses significant antimicrobial activity and protective effects against 5-FU-induced intestinal injury.
- The findings support HECL's traditional use and suggest its potential as a therapeutic adjuvant for gastrointestinal disorders.
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