Neurodegeneration and Homelessness: A Bidirectional Relationship Shaping Health and Vulnerability

Area of Science:

• Neuroscience
• Public Health
• Social Determinants of Health

Background:

• Homelessness involves conditions like stress and trauma that accelerate cognitive decline.
• Neurocognitive impairment increases vulnerability to homelessness due to difficulties with daily functioning.
• A reinforcing cycle exists where neurodegeneration leads to housing loss, and homelessness intensifies neurodegeneration.

Purpose of the Study:

• To highlight the underrecognition and underdiagnosis of neurodegenerative conditions in people experiencing homelessness.
• To examine the bidirectional relationship between neurodegeneration and homelessness.
• To identify effective strategies for improving recognition and care.

Main Methods:

• Literature review and synthesis of existing evidence on neurodegeneration and homelessness.
• Analysis of the pathways linking homelessness conditions to cognitive decline.
• Examination of diagnostic challenges and impacts of delayed diagnosis.

Main Results:

• Neurodegenerative conditions are prevalent but often missed in homeless populations.
• Fragmented care and symptom overlap hinder timely diagnosis.
• Delayed diagnosis leads to functional decline, relationship issues, and increased system encounters.

Conclusions:

• Addressing the neurodegeneration-homelessness link is vital for reducing suffering and promoting stability.
• Trauma-informed, harm reduction approaches like mobile outreach and Housing First show promise.
• Integrated care models are essential for improving neurological health and quality of life.