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POLA1 mediates hexavalent chromium-induced ovarian tumor progression through replication stress and DNA damage

Haoran Guo1, Zeqing Sun2, Mengzhen Li3

  • 1School of Public Health, Shandong Second Medical University, Weifang, Shandong 261053, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Department of Gynecology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China.

Toxicology
|April 1, 2026
PubMed

Keywords:
DNA damage response (DDR)Hexavalent chromium (Cr(VI))Ovarian cancerPOLA1Replication stress

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