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Correction: Intravenous thrombolysis for acute central retinal artery occlusion: Protocol for a systematic review and individual participant data meta-analysis of randomized controlled trials.

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Acute retinal artery occlusions.

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Related Experiment Video

Updated: Apr 3, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
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Update on Acute Retinal Arterial Ischemic Disorders.

Étienne Bénard-Séguin1, Brian Mac Grory2, Nancy J Newman3

  • 1Department of Surgery (Ophthalmology), University of Calgary, Alberta, Canada; Department of Clinical Neuroscience, University of Calgary, Alberta, Canada.

Neurologic Clinics
|April 1, 2026
PubMed
Summary
This summary is machine-generated.

Acute retinal artery occlusions cause sudden vision loss, similar to strokes. Early diagnosis and stroke evaluation are crucial, with ongoing trials exploring intravenous thrombolysis effectiveness within 4.5 hours.

Keywords:
Branch retinal artery occlusionCentral retinal artery occlusionEye strokeOcular imagingRetinal ischemiaThrombolysis

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Area of Science:

  • Ophthalmology
  • Neurology
  • Vascular Medicine

Background:

  • Acute retinal artery occlusions (AR O) manifest as sudden, painless monocular vision loss, mirroring cerebral ischemic strokes.
  • Diagnosis relies on ocular fundus examination, fundus photography, and optical coherence tomography.
  • Standard stroke evaluation is recommended, alongside giant cell arteritis screening for patients aged 50+.

Purpose of the Study:

  • To summarize the current understanding and diagnostic approaches for acute retinal artery occlusions.
  • To review potential treatment strategies, including emerging thrombolytic therapies.
  • To highlight the importance of timely diagnosis and stroke workup in managing AR O.

Main Methods:

  • Review of diagnostic modalities including fundus photography and optical coherence tomography.
  • Analysis of standard stroke evaluation protocols applicable to AR O.
  • Examination of evidence for intravenous thrombolysis (tPA) in acute settings.

Main Results:

  • Acute retinal artery occlusions require prompt diagnosis via fundus examination and imaging.
  • Standard stroke workup and giant cell arteritis screening are essential components of patient management.
  • Meta-analyses suggest potential benefits of intravenous tPA within 4.5 hours of symptom onset.

Conclusions:

  • Acute retinal artery occlusions are ophthalmic emergencies requiring immediate medical attention.
  • Thrombolytic therapy is an area of active investigation for improving outcomes.
  • Multidisciplinary evaluation is key for effective management and prevention of recurrence.