Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discontinuation and non-publication of atrial fibrillation clinical trials: A retrospective analysis of 538 trials.

International journal of cardiology. Heart & vasculature·2026

Same author

Real-world adverse events and device failure modes of the sentinel cerebral protection system: An analysis of the FDA MAUDE database 2022 to 2026.

Cardiovascular revascularization medicine : including molecular interventions·2026

Same author

The nonlinear trajectory of post-stroke aphasia recovery.

Frontiers in human neuroscience·2026

Same author

Device-specific failure patterns of guide catheter extensions in percutaneous coronary intervention: A contemporary MAUDE database analysis (2022-2025).

Cardiovascular revascularization medicine : including molecular interventions·2026

Same author

Corneal thinning and perforation: a narrative review of diagnostic and stepwise management strategies.

International ophthalmology·2026

Same author

Comment on: Efficacy of intracameral moxifloxacin in prevention of postcataract surgery endophthalmitis: randomized control trial.

Journal of cataract and refractive surgery·2026

Same journal

Neuro-Ophthalmology.

Neurologic clinics·2026

Same journal

Updates on Treatment in Thyroid Eye Disease for the Neurologist.

Neurologic clinics·2026

Same journal

Pediatric Optic Neuritis: An Update on Diagnosis and Management.

Neurologic clinics·2026

Same journal

Neuro-Ophthalmic Complications of Immune Checkpoint Inhibitors.

Neurologic clinics·2026

Same journal

Updates on Spaceflight-Associated Neuro-Ocular Syndrome: Intracranial Changes.

Neurologic clinics·2026

Same journal

Virtual Reality Testing in Neurology and Neuro-ophthalmology.

Neurologic clinics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 3, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Updates on Giant Cell Arteritis.

Abdee Ryalat¹, Own Khraisat², Yara Abukhaled³

¹Private Clinic, Suleiman Al-Hadidi Street, Amman 11183, Jordan.

Neurologic Clinics

|April 1, 2026

Summary

This summary is machine-generated.

Giant cell arteritis (GCA) is a serious vasculitis affecting older adults, posing risks for vision loss and stroke. Advances include faster diagnosis via ultrasound and new treatments like tocilizumab, moving beyond steroids.

Keywords:

Giant cell arteritis Glucocorticoids JAK inhibitor Large-vessel vasculitis Temporal arteritis

More Related Videos

Mouse Models for Graft Arteriosclerosis

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

Related Experiment Videos

Last Updated: Apr 3, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Mouse Models for Graft Arteriosclerosis

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

Area of Science:

Rheumatology
Neurology
Vascular Medicine

Background:

Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large and medium arteries in individuals over 50.
It presents a neurologic emergency due to risks of vision loss and stroke.
Diagnostic delays and limited treatment options have historically been challenges.

Purpose of the Study:

To summarize recent advances in the diagnosis and treatment of giant cell arteritis.
To highlight the shift towards noninvasive diagnostics and steroid-sparing therapies.

Main Methods:

Review of recent literature and clinical trial data on GCA.
Focus on advancements in diagnostic tools like vascular ultrasound.
Analysis of evolving treatment strategies, including biologic agents.

Main Results:

Rapid, noninvasive diagnosis is now feasible with bedside vascular ultrasound and updated imaging guidelines.
Treatment paradigms have shifted from glucocorticoid monotherapy to steroid-sparing regimens.
Tocilizumab (an interleukin-6 blocker) is an established treatment option.
Emerging therapies targeting JAK-STAT, GM-CSF, and IL-17 pathways are under investigation.

Conclusions:

Significant progress has been made in diagnosing and managing giant cell arteritis, reducing diagnostic delays.
The treatment landscape is evolving towards more targeted and steroid-sparing approaches.
While promising, further research is needed for novel therapeutic pathways.