Enhanced Self-Powered Wound-Healing Performance Mediated by Wearable Perfluorinated Polysuccinimide Nanocomposites...

Triboelectric nanogenerators (TENGs) have emerged as powerful tools in wearable electronics, allowing us to harness electricity generated from biomechanical forces using a miniaturized, biocompatible platform. A variety of commercially available polymers with different dielectric properties are typically used for TENGs; however, it is still a significant challenge to precisely and systematically control the degree of triboelectric properties. Herein, a polysuccinimide (PSI) with a controlled degree of perfluorination ("PF-PSI") is developed and implemented for TENG applications. Since PSI consists of a series of succinimidyl ring moieties capable of nucleophilic ring-opening reactions with amine-based molecules under ambient conditions, PF-PSI can be conveniently synthesized by direct conjugation with perfluoroalkylamines. The triboelectric properties of PF-PSI can be fine-tuned over a wide range by controlling the degree of perfluorination via the feed molar ratio and type of perfluoroalkyl amine, with a triboelectric potential of 9-50 V and power density of 0.06-55 μW cm^-2. A nanocomposite film infused with PF-PSI nanofibers, demonstrating enhanced mechanical properties, is developed and explored as a TENG to provide electrical stimulation (ES) to induce tissue regeneration. Up to 85% wound closure is achieved in 9 days with ES from the PF-PSI TENG, effectively demonstrating its therapeutic potential.