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Mosapride as a Pre-Endoscopy Preparation in a Patient Receiving GLP-1 Receptor Agonist Therapy
Kazuki Inoue1, Toshiyuki Morisawa1, Kenji Iguchi1
1Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Japan.
Abstract:
We present the case of a 66-year-old man who underwent upper gastrointestinal (GI) endoscopy and developed significant gastric residue after treatment with a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA) for type 2 diabetes. Despite prolonged fasting, large volumes of gastric residue persisted, thus impairing mucosal visualization. Instead of discontinuing GLP-1RA therapy, mosapride citrate was introduced as a gastroprokinetic agent. Three days before endoscopy, the patient received mosapride, which resulted in complete gastric clearance and optimal endoscopic visualization. This case suggests that mosapride may be an effective pre-endoscopic preparation to counteract GLP-1RA-induced delayed gastric emptying.
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