Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for longitudinal two-photon calcium imaging and holographic optogenetic manipulation to investigate memory in mice.

STAR protocols·2026
Same author

Highly Selective Dimerization of 3-Trioxotriangulene Mediated by Delocalized π-Radical Character on Au(111).

Journal of the American Chemical Society·2026
Same author

Trefoil polymers from a knotted synthon.

Nature chemistry·2026
Same author

Beclin-1/LC3B regulation of podocyte autophagy in IgA nephropathy via PI3K/AKT signaling.

Journal of nephrology·2026
Same author

Controlled Synthesis of Topologically Diverse Polyrotaxanes by Ring-Opening Polymerization of Mechanically Interlocked Monomers.

Journal of the American Chemical Society·2026
Same author

Ultrafast Photothermal Conversion of Ru/Zn Heterometallic Metal-Organic Framework for Synergistic Catalytic CO<sub>2</sub> Fixation.

Journal of the American Chemical Society·2026
Same journal

Decoding Galectin-Glycan Recognition with <sup>19</sup>F-Tagged Lectins: from Simple Glycans to the Cellular Glycocalyx.

Journal of the American Chemical Society·2026
Same journal

Open- and Closed-Shell Roles of Sensitizer and Annihilator in Pseudo-Single Component Mixtures for Upconversion.

Journal of the American Chemical Society·2026
Same journal

Pressure-Induced Superconductivity at 15 K in van-der-Waals Ferroelectric CuInP<sub>2</sub>S<sub>6</sub>.

Journal of the American Chemical Society·2026
Same journal

Carbene Analogues of Group 15: Reduction of s-Hydrindacene-Based Chloropnictogenium Ions To Access an Antimony Hydride Monocation and a Trinuclear Bismuth Dication.

Journal of the American Chemical Society·2026
Same journal

Chiral-Ligand-Modulated Nickel-Catalyzed Stereoselective Radical Migratory C2-Arylation of Carbohydrates.

Journal of the American Chemical Society·2026
Same journal

Coordination-Constraint-Driven Enhanced Chirality Induction in Perovskite Quantum Dot Solids.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Fabricating Nanogaps by Nanoskiving
07:36

Fabricating Nanogaps by Nanoskiving

Published on: May 13, 2013

11.7K

Resolving Solution-Synthesized Graphyne-Graphdiyne Macromolecules at the Angstrom Level.

Feng Su1,2, Mianling Huang1, Minjian Liao1

  • 1State Key Laboratory of Radio Frequency Heterogeneous Integration, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China.

Journal of the American Chemical Society
|April 1, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed new methods for characterizing large molecules using electrospray ionization scanning tunneling microscopy (ESI-STM). This technique achieves angstrom-level resolution, overcoming previous limitations in imaging complex macromolecules.

More Related Videos

Synthesis and Functionalization of 3D Nano-graphene Materials: Graphene Aerogels and Graphene Macro Assemblies
10:23

Synthesis and Functionalization of 3D Nano-graphene Materials: Graphene Aerogels and Graphene Macro Assemblies

Published on: November 5, 2015

14.6K
Microscopic Visualization of Porous Nanographenes Synthesized through a Combination of Solution and On-Surface Chemistry
08:18

Microscopic Visualization of Porous Nanographenes Synthesized through a Combination of Solution and On-Surface Chemistry

Published on: March 4, 2021

2.3K

Related Experiment Videos

Last Updated: Jun 14, 2026

Fabricating Nanogaps by Nanoskiving
07:36

Fabricating Nanogaps by Nanoskiving

Published on: May 13, 2013

11.7K
Synthesis and Functionalization of 3D Nano-graphene Materials: Graphene Aerogels and Graphene Macro Assemblies
10:23

Synthesis and Functionalization of 3D Nano-graphene Materials: Graphene Aerogels and Graphene Macro Assemblies

Published on: November 5, 2015

14.6K
Microscopic Visualization of Porous Nanographenes Synthesized through a Combination of Solution and On-Surface Chemistry
08:18

Microscopic Visualization of Porous Nanographenes Synthesized through a Combination of Solution and On-Surface Chemistry

Published on: March 4, 2021

2.3K

Area of Science:

  • Macromolecular chemistry
  • Surface science
  • Nanotechnology

Background:

  • Characterizing complex macromolecules in solution is challenging.
  • Electrospray ionization scanning tunneling microscopy (ESI-STM) shows promise for nonsublimable molecules.
  • High-resolution imaging is hindered by weak ionization and solubilizing groups.

Purpose of the Study:

  • To develop advanced ESI-STM techniques for high-resolution characterization of complex macromolecules.
  • To overcome limitations in ionization efficiency and imaging interference from solubilizing groups.
  • To achieve angstrom-level resolution for structural and electronic mapping.

Main Methods:

  • Synthesis of graphyne-graphdiyne macrocycles functionalized with triphenylamine groups.
  • Enhancement of ionization efficiency using triphenylamine moieties.
  • Single-molecule tip manipulation and bromine-assisted thermal treatment for solubilizing group removal.
  • Acquisition of bond-resolving images and angstrom-resolution molecular orbital maps via ESI-STM.

Main Results:

  • Successfully synthesized graphyne-graphdiyne macrocycles with enhanced ionization.
  • Developed novel methods for removing interfering solubilizing groups.
  • Achieved unprecedented bond-resolving structural images of macromolecules.
  • Obtained angstrom-resolution frontier molecular orbital maps.

Conclusions:

  • The developed methods bridge the gap between solution-phase synthesis and high-resolution STM characterization.
  • Angstrom-level resolution for complex macromolecules is now achievable.
  • This work advances the capabilities of ESI-STM for detailed molecular analysis.