Asprosin as a Potential Link Between Vascular Inflammation and Disease Activity in Behçet's Disease

Area of Science:

• Immunology
• Endocrinology
• Rheumatology

Background:

• Behçet's disease (BD) is a chronic multisystem vasculitis.
• Endothelial dysfunction and vascular inflammation are key features of BD.
• Asprosin, an adipokine, is linked to endothelial injury and inflammation.

Purpose of the Study:

• Investigate serum asprosin concentrations in BD patients.
• Determine the relationship between asprosin levels and BD disease activity.
• Assess the association of asprosin with clinical manifestations and inflammatory markers.

Main Methods:

• Cross-sectional case-control study with 49 BD patients and 48 controls.
• Serum asprosin quantified using ELISA.
• Disease activity stratified; associations analyzed via correlation and multivariate analysis.

Main Results:

• Elevated serum asprosin in BD patients compared to controls (p < 0.001).
• Asprosin levels increased with disease activity (p < 0.001).
• Higher asprosin in patients with vascular involvement and uveitis (p < 0.01); positive correlation with CRP (r=0.431, p=0.002).

Conclusions:

• Serum asprosin is elevated in Behçet's disease.
• Asprosin levels correlate with disease activity, inflammation, and organ involvement (vascular, uveitis).
• Asprosin may serve as a biomarker for inflammatory and vascular burden in BD.